Extremely strong tubular stacking of aromatic oligoamide macrocycles† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc02380c Click here for additional data file.

Large ring-forming alkylations provide facile access to composite macrocycles† †Electronic supplementary information (ESI) available: Fig. S1–S4, list of macrocycles prepared, experimental procedures, and spectroscopic data. CCDC 1023942. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc03848g Click here for additional data file. Click here for additional data file.

Macrocyclic compounds have potential to enable drug discovery for protein targets with extended, solventexposed binding sites. Crystallographic structures of peptides bound at such sites show strong surface complementarity and frequent aromatic side-chain contacts. In an effort to capture these features in stabilized small molecules, we describe a method to convert linear peptides into constrai...

Polycyclic aromatic azomethine ylides: a unique entry to extended polycyclic heteroaromatics† †Electronic supplementary information (ESI) available. CCDC 1022817 and 1022816. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02793k Click here for additional data file. Click here for additional data file.

Crystallization-induced dual emission from metal- and heavy atom-free aromatic acids and esters† †Electronic supplementary information (ESI) available. CCDC 1044990 and 1044991. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc00253b Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

Orthogonal functionalisation of α-helix mimetics† †Electronic supplementary information (ESI) available: Additional binding data and fluorescence characterisation. Experimental procedures and characterisation of all new compounds. See DOI: 10.1039/c4ob00915k Click here for additional data file.

α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors.

All-metal aromatic cationic palladium triangles can mimic aromatic donor ligands with Lewis acidic cations† †Electronic supplementary information (ESI) available: Reaction procedures, characterization of complexes, copies of all spectra and cif files, modelling details and XYZ coordinates. CCDC 1410440–1410442. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc03475j Click here for additional data file. Click here for additional data file.